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A stroke is primarily caused by a disruption of blood flow to the brain, which can occur when there is a blood clot blocking a blood vessel—this is often referred to as an ischemic stroke. When this happens, the affected brain cells begin to die due to a lack of oxygen and nutrients, leading to the various symptoms associated with a stroke, such as weakness, speech difficulties, or paralysis. The presence of a blood clot is a significant factor in this process, making it a critical understanding in the context of recognizing and responding to strokes.

Other options, while potentially serious medical conditions, do not accurately describe the primary cause of a stroke. Excessive bleeding can lead to a range of serious health issues but is less directly related to the mechanism of stroke. Heart failure relates to the heart's capacity to pump blood effectively, and low blood pressure may affect circulation but doesn't primarily cause a stroke in the same manner as a blood clot. Understanding these distinctions is essential for recognizing the signs of stroke and responding appropriately in emergencies.